Validated and selective potentiometric analysis of anti-coagulant edoxaban via a screen-printed electrode: green assessment by Eco-Scale and Complex-GAPI

Abstract Thromboembolism because of coronavirus infection (COVID-19) resulted in increasing the number sudden deaths after recovery. So, patients were switched to edoxaban tosylate monohydrate (EDTM) therapy low molecular weight heparin shorten hospitalization period. In response increase demand for EDTM, we developed a home-made screen-printed electrode determine EDTM its pure form and pharmaceutical dosage form. Optimized conditions achieved with utilizing EDTM-Phosphotungstic acid (EDTM-PTA) as an ion pair complex plasticizer dibutyl phthalate Nernstian slope 58.78 ± 0.1 mV decade −1 at concentrations ranging from 5.0 × 10 –6 1.0 –2 M ( R 2 = 0.9985). The detection limit was 4.3 M. Our method proven be eco-friendly assessment by Eco-Scale Complex-GAPI. results obtained validated according ICH guidelines found agree those gained reference method.